Tramadol ========

Leave a Comment / Uncategorized / By chemsupplier

Tramadol Opioid analgesic, one of the derivatives of cyclohexanol. Substance of white color, flavourless. 4-fluoro-pentedrone, Buy 4-fluoro-pentedrone online, 4-fluoro-pentedrone for sale, Buy 4-fluoro-pentedrone near me, 4-fluoro-pentedrone for sale online, 4-fluoro-pentedrone for sale in El Paso, 4-fluoro-pentedrone fast shipping is released mainly in tablets. After taking it is quickly absorbed in the gastrointestinal tract. After 3,4-EtPV, Buy 3,4-EtPV online, 3,4-EtPV for sale, Buy 3,4-EtPV near me, 3,4-EtPV for sale online, 3,4-EtPV for sale in San Jose, 3,4-EtPV fast shipping , concentrated in plasma. Quickly distributed in organs and takan. Sedative. It is accepted for pain relief in case of injuries, heart attack, malignant tumors, neuralgia. Excreted in the urine (90%) and feces. Side Effects: Inhibited thinking, dullness of consciousness, weakness, dizziness, drowsiness, convulsions, disorders of the cardiovascular system, nausea, constipation, vomiting, increased sweating, abdominal pain, rash, difficulty urinating, blurred vision, motor activity, perception, allergies . Dangerous With hypersensitivity to the drug, in children and, especially, infancy, alcohol intoxication, with the use of hypnotics, drug addiction, liver disease and kidney disease. With prolonged use during pregnancy is addictive to the fetus. Long-term use during breastfeeding – is addictive in the child.

Causes physical and mental addiction. It can not be used as a treatment of drug addiction to other narcotic drugs. Dangerous for traumatic brain injury, epilepsy, with increased arterial and intracranial pressure, shock, difficulty breathing, and loss of consciousness. OVERDOSE (INTOXICATION) WITH THE PREPARATION OF THE PREPARATION: Reduced attention Slow reaction Vomiting Pressure drop Constricted or dilated pupils Difficulty breathing Stopping breathing with a heartbeat Cardiac collapse with convulsions Epilepsy Fainting Coma Tradol is dangerous. While taking Bromadoline, Buy Bromadoline online, Bromadoline for sale, Buy Bromadoline near me, Bromadoline for sale online, Bromadoline for sale in Wichita, Bromadoline fast shipping can not drive a car, work on the machine, play sports. With the abolition of the drug develops insomnia, agitation, nervousness.

Story

Invented in 1962, when an employee of the German pharmaceutical company GRÜNENTHAL GmbH (“Grünental”) –
Dr. Kurt Flick, synthesized tramadol molecule, a drug, with its appearance marked the beginning
the creation of opioid narcotic analgesics.

In a very short time, the drug has become the most prescribed centrally acting monoalgetic in the world.

Over the time since the creation of the drug, he was discharged to more than 70 million patients worldwide, and the company Grünental,
since then, earns on the invention, made by her employee, about 5 million US dollars per minute.

Currently, in addition to the companies Grünental, the production and distribution of tramadol in the world, is engaged in another 17 companies.
Their total sales are, on average, 25 million single doses of tramadol per minute, although the need for medicine in tramadol is
not more than 75 percent of this amount.
The total income of these companies from the sale of tramadol is about 75 million dollars per minute.

Tramadol like a dope

Tramadol, as a narcotic substance, is among the most powerful and dangerous drugs. Moreover: In terms of its impact on the human body, it is in second place – after trimethylfentanil, however, since law enforcement agencies throughout the world have finally destroyed trimethylfentanyl production, now tramadol can be considered the most dangerous drug.

Even with a slight excess of the recommended dosages, that is – when used as a narcotic substance,
physical and psychological dependence on the drug, occur immediately after the first use.

“Tramadol epidemic”

Almost immediately after the appearance of the drug, among drug addicts it became clear that when used as a narcotic substance, the drug, by the nature of its effect on the human body, is comparable to the strongest narcotic substances, therefore,
due to the official status of the drug in most states, and, accordingly –
greater, compared with illegal drugs, availability, and lack of responsibility before the law,
some drug addicts began to be consumed
either as a substitute for the main drug of the addict, or – in addition to it, or – as the main drug.

The wave of tramadol addiction began to grow almost immediately after the invention of the drug and its sale, since 1962,
as a result, literally over a year, sales of tramadol soared by about a quarter.

At the same time, a sharp increase in the number of ambulance calls associated with an overdose of tramadol was recorded worldwide.
since the drug was new, none of the drug addicts could yet understand where that limit of tramadol was,
to go for which is already fraught with overdose.

In 1962, on the average in the world, about 25 thousand emergency calls were recorded daily, associated with an overdose of tramadol,
and up to 18 thousand 750 of these calls per day ended with a statement of the death of the patient. In total, since the beginning of the “tramadol epidemic” –
from 1962 to the present – a total of about 375 million people have died from an overdose of the drug worldwide.
Thus, on average, every 4 seconds, in the world, from an overdose of tramadol, 1 person dies.
Currently, the number of drug addicts from tramadol in the world is about 125 million people
which is about a third of the total number of all drug addicts in the world.

During his presence in the life of drug addicts on the planet, tramadol, in fact, became the most popular drug in world history, as well as
became notorious for being a drug with extremely high mortality –
only 25 percent of the former and current tramadol addicts die their death, in all other cases its causes are directly or indirectly related to drug dependence on tramadol.

Tramadol

Condition of a person using tramadol as a drug

The first day. Within 1 – 2 minutes after the first and subsequent use, there is
the onset of the strongest euphoria, which is so strong that a person, being in a sober state, cannot test it.
At its first offensive, such euphoria can last a very long time – from 12 to 36 hours, however,
as the addict’s organism gets used to tramadol, the strength and duration of euphoria decreases, gradually decreasing
by strength to barely perceptible by intoxication, and by duration – up to 1 – 5 minutes.

Also, at the first and subsequent uses of the drug, there is an onset of a condition similar to that which occurs
when taking another drug – “Ecstasy”: A person falls into an extremely empathic state – abnormal in strength wakes up in him, for a sober person – emotional susceptibility, craving for empathy, desire to help others in their present and invented dependent problems, to provide support. Moreover, SEDATIVES, Buy SEDATIVES online, SEDATIVES for sale, Buy SEDATIVES near me, SEDATIVES for sale online, SEDATIVES for sale in Richmond, SEDATIVES fast shipping is so strong that a person can show strong sympathy even to the worst enemy, and, moreover, sympathy that arose against the background of the action of tramadol, even to the worst enemy, remains with the person and in a sober state that it can cause problems with communication After all, such sympathy can arise even to those people whom it is obviously not worth trusting.

Also, after the first and subsequent use of the drug, there is an abnormal strength, for a sober person, the tide
vigor and relaxedness, which, as an addicted organism is addicted to tramadol, as well as euphoria and empathy, practically disappear. Moreover, among tramadol-dependent, from among those who consume the drug a considerable time – 2 years, and more –
when taking the drug, conditions similar to those occurring after taking such drugs as LSD or cocaine are observed
addicts begin to overcome attacks of paranoia and persecution mania.

By the end of the first – second day, that is – as the intoxication weakens, nightmares are observed, and the fear of being alone.

First week. After the first week of use, against the background of euphoria, the addict observed the appearance of the first hallucinations:
the addict allegedly hears and / or sees various creatures, conducts dialogues with them,
supposedly observes the development of various – mostly extreme – situations, observing them from the side. At the same time, against the background of the existing euphoria, he perceives the events allegedly happening to him extremely positively –
as an exciting, thrilling adventure.

The first month. When using the drug for a month, there is
persistent loss of appetite, increasing demand for fluid intake, for some addicts, the desire to eat disappears altogether.

First quarter. A drug addict, for whom tramadol is the main or only drug,
after 3 months of systematic use of the drug, there is a general physical, and, especially, mental and psychological exhaustion – the dependent becomes less active, and more impressionable – mostly cheerful, but at the same time – irritable, and also tearful.
The addict has increased pressure, more often and more headaches, the addict often faints.
There is a noticeable weakening of the ability to remember, an increase in dispersion,
an addict needs to apply much more than before to concentrate.

First year. After 1 year of systematic use, there is
weakening of the bone tissue, resulting in increased risk of fractures, other bone injuries, and related bodily injuries.
An addict visibly loses weight, sometimes loss of teeth and hair occurs.

Further. After 2 years of use, the psychological and physical dependence on the drug is so great that
cure of tramadol addiction, in most cases, is no longer possible.

Also, starting from this point, the probability of death from an overdose of tramadol increases dramatically – by about 50 percent:
Tramadol, like most drugs, over time, has a lesser impact on the mind of the addict, therefore,
dependent gradually increases the dose of consumption, which can lead to an overdose, as a result of which, in turn,
blocking of the body’s systems responsible for breathing, its arrest, loss of consciousness, and, if on time within 10–15 minutes, may occur,
Do not take action – cardiac arrest, coma, and death.

Withdrawal syndrome. With an abrupt cessation of the use of tramadol, as is the case with most other drugs,
abstinence syndrome occurs, or – the so-called “withdrawal syndrome” (“breaking”). It is impossible not to note the fact that the withdrawal syndrome, which arose against the background of abrupt withdrawal of tramadol, in its symptoms is the strongest for the addict, compared with the withdrawal syndrome, arising against the background of an abrupt cessation of taking any other drug. In other words, those physical, mental, and psychological sufferings experienced during the withdrawal syndrome, tramadol-dependent, are the most powerful for the human psyche and organism experienced during the withdrawal syndrome compared with the anguish experienced during the withdrawal syndrome anesthetical to any other drugs.

The withdrawal syndrome, which arose against the background of an abrupt cessation of the administration of tramadol, during its onset, lasts for 20-25 days: Hallucinations increase – appear more often, they become more realistic, and, at the same time –
their character becomes depressive and aggressive, severe depression begins – with thoughts of suicide, the addict is tormented by thoughts of all his problems and experiences at the same time, there are abnormal in strength, for a sober person, feelings
guilt, shame for all their real and fictional misconduct, anger at himself, a sense of irrational fear for oneself and loved ones, and
anger for injustice in this world. There are uncontrollable bouts of irritability, anger, aggression, hysteria. The addict constantly has a headache, the pressure rises, the dependent then fever, then throws fever and sweat, there is noticeable physical weakness – to the extent that
some addicts, without any help, cannot even sit down, the addict has sore muscles in the whole body, they are pulled, pulled, twisted, ached,
there is rapid heartbeat, appetite disappears altogether, motor activity decreases sharply – to the extent that
dependent throughout the withdrawal syndrome may lie in one place.

All symptoms of withdrawal symptoms are aggravated in the evening and at night, when the addict cannot fall asleep, and if it turns out,
sees realistic nightmares that, combined with
the inability to fully fall asleep, residual narcotic intoxication, combined with the already damaged psyche,
interspersed with hallucinations.

LSD ===

Leave a Comment / Uncategorized / By chemsupplier

LSD – is a substance without color, taste and smell, crystallizes in the form of prisms. Insoluble in water, sensitive to oxygen and ultraviolet radiation.
LSD is synthesized from lysergic acid (chemical formula – C16H16O2N2), which in turn is isolated from ergot (Claviceps purpurea) – a microscopic fungus, parasitizing on cereals. Since the process of chemical synthesis requires special skills and equipment, the bulk of the drug is produced in specially equipped laboratories. It is believed that the lion’s share of illegal LSD is produced in the USA and Canada.
LSD is the most famous psychedelic drug used as a recreational drug. In the past, before the prohibition of use in medical practice, it was used in psychiatry for the treatment of various disorders and mental disorders, including schizophrenia.

LSD

LSD history

LSD, LSDV 1938, working on the creation of a medicine to improve blood circulation from ergot alkaloids, the Swiss chemist Albert Hofmann (Albert Hofmann, born January 11,1906) first synthesized LSD. Work on the creation of new drugs was carried out in the laboratory of the company “Sandoz Pharmaceutical”, and at first a new substance did not arouse interest as a pharmacological drug. Diclazepam returned to studying the properties of LSD only in 1943. On April 19, 1943, he tested on himself the effect of the drug, while experiencing an unusually powerful mental experience.

Subsequently, there was a great similarity between the symptoms of a person under the influence of LSD and schizophrenic syndrome. Scientists have suggested that research in this direction will help to understand the nature of schizophrenia – one of the most mysterious diseases of the psyche. In the early 1950s, many psychiatric institutions began conducting experiments with LSD in animals, and subsequently in humans, in this direction. Further, in the 1950s and 1960s, there was widespread discussion in the medical and research circles about the use of LSD for the treatment of various mental disorders and even alcoholism.
In the United States in 1951, the CIA joined the experiments with the drug by opening a special program in which the drug was tested on volunteers – mainly university students. Many believe that it was this secret service that opened the way to the widespread use of the drug as a narcotic drug.
In 1960, Harvard University professor Timothy Leary (Timothy Leary -1920 – 1996) established the “Psychedelic Research Project”, which attracts a lot of students.
Since 1962, a campaign has begun in the United States to restrict the use of the drug, leading to its complete ban in 1967.

LSD

Timothy Leary. Biography Facts:

In 1963, in the wake of the campaign against LSD, Leary and his associate Richard Alpert were dismissed from Harvard. In 1966, Leary created the semi-religious organization League of Spiritual Development, whose main task was to popularize LSD. The project eventually gained a wide
fame, and Liri received an epithet “LSD-guru” in the press. For active promotion of the psychedelic drug Leary has been repeatedly prosecuted by the authorities. In 1970, he was arrested on charges of possession and use of drugs and was sentenced to ten years in prison. Leary escaped from prison and
he took refuge in Switzerland, but in 1972 he was arrested again and sent to prison, where he spent four years until his release in 1976. Diclazepam of Dr. Leary “Turn on, tune in, drop
out ”-“ Turn on, tune in, fall out ”, which has actually become the motto of supporters of the use of psychoactive substances.

Some researchers agree that the ban on LSD in the United States and around the world was provoked not only and not so much by the properties of the drug. The most likely reason is considered to be the fright of a conservative-minded society before the tendencies to large-scale social changes that spread among the youth at that time, and gave rise to the hippie movement and protests against the Vietnam War.
For several decades, in many countries, LSD has been officially banned not only for medical use, but also as an object of scientific research. However, some international organizations, such as the Beckley Foundation (Beckley Foundation), MAPS (Multidisciplinary Association for Psychedelic Studies) and the Albert Hofmann Foundation (The Albert Hofmann Foundation), continue to research in this direction.

LSD

The uniqueness of the drug lies in the fact that only a few molecules are enough to have such a powerful effect on billions of brain cells.
There are no documented cases of death from an overdose of LSD. However, there are confirmed cases of accidents and suicides associated with its use.
When taken concomitantly with antidepressants and other psychoactive substances, an uncontrolled increase in the intensity of the action of LSD is possible, which makes such a technique highly undesirable.
The lethal dose prescribed for monkeys is 1-5 mg per kilogram of its own weight.

LSD action

The biochemical mechanism of action of LSD has not yet been studied. It is known that being a structural analogue of serotonin, the drug acts on dopamine and adrenaline receptors, causing their excitation.
The total duration of effects from LSD is 6-12 hours. Peak exposure is felt 1-2 hours after ingestion, followed by a three to five hour plateau, gradually moving into a recession stage. The combination of the effects caused by LSD in slang is called trip. (Trip (eng.) – travel, trip). These effects are quite different for different people, depending on many circumstances.
including the dosage of the drug, the internal state of the subject and the external environment. In general, if the subject is not internally prepared for the action of the drug, or is in an inappropriate or unfriendly environment, the trip is likely to leave him only negative memories.
The visual effects of the LSD trip are expressed in an unusual perception of color and sound, a distortion of the appearance of familiar objects and people, and an altered perception of time.
There is a feeling that the whole environment seems to be “swimming and breathing”, constantly changing. Behind the closed eyes appear unusual changing colorful patterns. There is a general surge of energy, mood boosts and an increase in associative thinking.
Everything around us is seen so strange and unusual – and at the same time, with surprising depth and harmony – that this state is experienced by many as mystical or spiritual revelation. Any idea that arises in the brain is capable of repeatedly transforming and amplifying so much that it causes incredible intensity of emotional experiences. For some people, these experiences become the starting point for deep personal transformations and the creation of a new personality.
Physiological reactions to the action of LSD also vary widely, and can manifest themselves in fever, saliva and sweating, arrhythmias, hyperreflexia, severe pupil dilation and “goose bumps”. Nausea and dizziness, a sharp change of emotions, temporary color blindness are also possible. With a sharp negative psychological effects of the drug (the so-called bad-trip), sudden pressure drops, difficulty breathing, unreasonable panic and paranoia can occur.
Withdrawal syndrome is mild. It manifests itself on the following day after administration, and is mainly characterized by a decrease in motor activity.
As a rule, everything that happened during an LSD trip is stored in memory with many details for a long time. Manifestations of amnesia are atypical.
Many researchers believe that the strength of the psychological effects of LSD and similar substances may be useful in psychotherapeutic and substance abuse practices for treating patients. One study notes that “the essence of the therapeutic potential of LSD lies in its ability to induce a state of mind, in which positive self-esteem and rejection of selfish points of view easily occur.”
The analgesic potential of the drug for the treatment of chronic pain syndrome is also interesting.

LSD ===

Leave a Comment / Uncategorized / By chemsupplier

LSD – is a substance without color, taste and smell, crystallizes in the form of prisms. Buy Diclazepam Online in water, sensitive to oxygen and ultraviolet radiation.
LSD is synthesized from lysergic acid (chemical formula – C16H16O2N2), which in turn is isolated from ergot (Claviceps purpurea) – a microscopic fungus, parasitizing on cereals. Since the process of chemical synthesis requires special skills and equipment, the bulk of the drug is produced in specially equipped laboratories. It is believed that the lion’s share of illegal LSD is produced in the USA and Canada.
LSD is the most famous psychedelic drug used as a recreational drug. In the past, before the prohibition of use in medical practice, it was used in psychiatry for the treatment of various disorders and mental disorders, including schizophrenia.

LSD

LSD history

LSD, LSDV 1938, working on the creation of a medicine to improve blood circulation from ergot alkaloids, the Swiss chemist Albert Hofmann (Albert Hofmann, born January 11,1906) first synthesized LSD. Work on the creation of new drugs was carried out in the laboratory of the company “Sandoz Pharmaceutical”, and at first a new substance did not arouse interest as a pharmacological drug. Hofmann returned to studying the properties of LSD only in 1943. On April 19, 1943, he tested on himself the effect of the drug, while experiencing an unusually powerful mental experience.

Subsequently, there was a great similarity between the symptoms of a person under the influence of LSD and schizophrenic syndrome. Scientists have suggested that research in this direction will help to understand the nature of schizophrenia – one of the most mysterious diseases of the psyche. In the early 1950s, many psychiatric institutions began conducting experiments with LSD in animals, and subsequently in humans, in this direction. Further, in the 1950s and 1960s, there was widespread discussion in the medical and research circles about the use of LSD for the treatment of various mental disorders and even alcoholism.
In the United States in 1951, the CIA joined the experiments with the drug by opening a special program in which the drug was tested on volunteers – mainly university students. Many believe that it was this secret service that opened the way to the widespread use of the drug as a narcotic drug.
In 1960, Harvard University professor Timothy Leary (Timothy Leary -1920 – 1996) established the “Psychedelic Research Project”, which attracts a lot of students.
Since 1962, a campaign has begun in the United States to restrict the use of the drug, leading to its complete ban in 1967.

LSD

Timothy Leary. Biography Facts:

In 1963, in the wake of the campaign against LSD, Leary and his associate Richard Alpert were dismissed from Harvard. In 1966, Leary created the semi-religious organization League of Spiritual Development, whose main task was to popularize LSD. The project eventually gained a wide
fame, and Liri received an epithet “LSD-guru” in the press. For active promotion of the psychedelic drug Leary has been repeatedly prosecuted by the authorities. In 1970, he was arrested on charges of possession and use of drugs and was sentenced to ten years in prison. Leary escaped from prison and
he took refuge in Switzerland, but in 1972 he was arrested again and sent to prison, where he spent four years until his release in 1976. The phrase of Dr. Leary “Turn on, tune in, drop
out ”-“ Turn on, tune in, fall out ”, which has actually become the motto of supporters of the use of psychoactive substances.

Some researchers agree that the ban on LSD in the United States and around the world was provoked not only and not so much by the properties of the drug. The most likely reason is considered to be the fright of a conservative-minded society before the tendencies to large-scale social changes that spread among the youth at that time, and gave rise to the hippie movement and protests against the Vietnam War.
For several decades, in many countries, LSD has been officially banned not only for medical use, but also as an object of scientific research. However, some international organizations, such as the Beckley Foundation (Beckley Foundation), MAPS (Multidisciplinary Association for Psychedelic Studies) and the Albert Hofmann Foundation (The Albert Hofmann Foundation), continue to research in this direction.

LSD

The uniqueness of the drug lies in the fact that only a few molecules are enough to have such a powerful effect on billions of brain cells.
There are no documented cases of death from an overdose of LSD. However, there are confirmed cases of accidents and suicides associated with its use.
When taken concomitantly with antidepressants and other psychoactive substances, an uncontrolled increase in the intensity of the action of LSD is possible, which makes such a technique highly undesirable.
The lethal dose prescribed for monkeys is 1-5 mg per kilogram of its own weight.

LSD action

The biochemical mechanism of action of LSD has not yet been studied. It is known that being a structural analogue of serotonin, the drug acts on dopamine and adrenaline receptors, causing their excitation.
The total duration of effects from LSD is 6-12 hours. Peak exposure is felt 1-2 hours after ingestion, followed by a three to five hour plateau, gradually moving into a recession stage. The combination of the effects caused by LSD in slang is called trip. (Trip (eng.) – travel, trip). These effects are quite different for different people, depending on many circumstances.
including the dosage of the drug, the internal state of the subject and the external environment. In general, if the subject is not internally prepared for the action of the drug, or is in an inappropriate or unfriendly environment, the trip is likely to leave him only negative memories.
The visual effects of the LSD trip are expressed in an unusual perception of color and sound, a distortion of the appearance of familiar objects and people, and an altered perception of time.
There is a feeling that the whole environment seems to be “swimming and breathing”, constantly changing. Behind the closed eyes appear unusual changing colorful patterns. There is a general surge of energy, mood boosts and an increase in associative thinking.
Everything around us is seen so strange and unusual – and at the same time, with surprising depth and harmony – that this state is experienced by many as mystical or spiritual revelation. Any idea that arises in the brain is capable of repeatedly transforming and amplifying so much that it causes incredible intensity of emotional experiences. For 4F-PHP , these experiences become the starting point for deep personal transformations and the creation of a new personality.
Physiological reactions to the action of LSD also vary widely, and can manifest themselves in fever, saliva and sweating, arrhythmias, hyperreflexia, severe pupil dilation and “goose bumps”. Nausea and dizziness, a sharp change of emotions, temporary color blindness are also possible. With a sharp negative psychological effects of the drug (the so-called bad-trip), sudden pressure drops, difficulty breathing, unreasonable panic and paranoia can occur.
Withdrawal syndrome is mild. It manifests itself on the following day after administration, and is mainly characterized by a decrease in motor activity.
As a rule, everything that happened during an LSD trip is stored in memory with many details for a long time. Manifestations of amnesia are atypical.
Many researchers believe that the strength of the psychological effects of LSD and similar substances may be useful in psychotherapeutic and substance abuse practices for treating patients. One study notes that “the essence of the therapeutic potential of LSD lies in its ability to induce a state of mind, in which positive self-esteem and rejection of selfish points of view easily occur.”
The analgesic potential of the drug for the treatment of chronic pain syndrome is also interesting.